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Activated by the antibiotic rifampicin and numerous plant metabolites, including hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-unique. Activated by Obviously happening steroids, like pregnenolone and progesterone. Binds to your reaction ingredient in the promoters of the CYP3A4 and ABCB1/MDR1 genes“W